Abstract: Systemic lupus erythematosus(SLE) is an autoimmune diseases featured with slow onset, insidious occurrence, clinical manifestations. SLE is involved in many system and organ autoimmune diseases and has an effect on skin, serosa, joints, kidney and central nervous system etc. Cellular and humoral immune dysfunctions produce many autoantibodies. Keywords: Systemic Lupus Erythematosus, Autoimmune Disease, Inflammation …
FineTest ELISA kits are used for the detection and quantification of therapeutic monoclonal antibodies such as Bevacizumab® and biosimilars including rituximab and adalimumab, as well as the immunogenicity detection of Anti-Drug Antibodies (ADAs). Advantages of These ELISA Kits High Specificity No cross-reaction with non-target human serum protein or immunoglobulin High Sensitivity High sensitivity and wide …
HCPs are cellular structural and secretory proteins produced during cell culture process. It’s reported that HCPs can stimulate the human immune system, triggering allergic reactions or other adverse responses. Besides, HCPs may induce the production of antibodies against protein drugs in the body, affecting the therapeutic effects of the drugs. ELISA assay is a widely …
Apoptosis(also called programmed cell death) is a kind of programmed and gene-controlled cell death type. It’s one of the key mechanisms for maintaining normal growth and homeostasis in organisms. Annexin V is the indicator for detecting early cell apoptosis, which has a high affinity for PS(photosensitive serine). In the early apoptosis, PS flips from the …
Abstract: Macrophages are derived from monocytes and produced by the differentiated monocytes in the blood. They’re a kind of leukocyte in the tissue. The volume, endoplasmic reticulum, mitochondria, lysosome and phagocytic function increases, after monocytes enter connective tissues. Some macrophage polarization markers are specified below. Keywords: Macrophage Polarization, Macrophage and Monocyte, Macrophage Function 1. Macrophage …
Lysosome Lysosomes are shaped variously and vesicular structures (0.025 to 0.8 micrometers in size) containing numerous hydrolytic enzymes. Their intracellular function is to break down external substances that have entered the cell, as well as to digest portions of the cell’s own cytoplasm or organelles. LAMP1 and LAMP2 are two transmembrane proteins located on the …
Abstract: Organelles are micro-organs which have specific morphology and function in the cytoplasm, mainly including mitochondrion, endoplasmic reticulum, centrosome, chloroplast, ribosome etc. They’re the basic cellular structure and maintain the normal working of the cell. Some organelle markers are specified below. Keywords: Organelle Marker, Ribosome, Endoplasmic Reticulum, Golgi bodies Graph Abstract 1. Ribosome Ribosome …
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1. Overview Isotype control antibodies refer to the immunoglobulin sharing the same species, subtype and dose as the primary antibody. It’s mainly applied in removing the background signal caused by non-specific binding. 2. The Purpose of Isotype Control We know that the antibody structure is divided into a constant region and a variable region. The …
1. Loading Control Antibodies Loading control antibodies are widely used in WB to detect loading control protein expression level and ensure accuracy of experimental results by correcting the error during protein quantitation and sample loading. Besides, loading control can be used as blank control to detect protein transmembrane situation, the staining or ECL process of …
