Cytokines ELISA Kits

Cytokines play an important role in signal transduction between cells. Intercellular substances are synthesized and secreted by stimulation. They regulate cell growth, differentiation and immune response to participate in cell activity via binding with relevant receptors. Cytokines contain interleukins, inflammatory factors, matrix metalloproteinases, growth factors, chemokines, colony-stimulating factors, interferons, tumor necrosis factors etc.

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Interleukins

Interleukins are cytokines produced by a variety of cells and have effect on many cells. They play an important role in maturity, activation, proliferation, and immune regulation of immune cells. Besides, they are involved in multiple physiological and pathological reactions of human body.

IL-1A IL-1B IL-1F10 IL-2 IL-3 IL-4 IL-5
IL-6 IL-7 IL-8 IL-9 IL-10 IL-11 IL-12
IL-12A IL-12p35 IL-12p40 IL-12P70 IL-12RB1 IL-13 IL-15
IL-16 IL-17 IL-17A IL-17A/F IL-17B IL-17D IL-17F
IL-18 IL-19 IL-20 IL-21 IL-22 IL-23 IL-23A
IL-24 IL-25 IL-26 IL-27 IL-28A IL-28B IL-29
IL-2RA IL-31 IL-32 IL-33 IL-34 IL-35 IL-36A
IL-36B IL-36G IL-37

Leukocyte Differentiation Antigens

CD differentiation cluster or group, also called leukocyte differentiation antigen, refers to different lineage of leukocytes appear or disappear during normal different stages of differentiation, maturity and activation. In physiology, CD molecules have many applications. Usually, they are used as important cell receptors or ligands, including T cells, B cells, myeloid cells, NK cells, platelets, activated antigens, adhesion molecules, endothelial cells, and cytokine receptors etc. Also as surface markers for cell identification and isolation, they're involved in cell growth, maturation, differentiation, development, migration, and activation.

CD2 CD3 CD3d CD3E CD4 CD5L CD8A
CD13 CD14 CD19 CD20 CD21 CD23 CD24
CD26 CD27 CD28 CD30 CD32 CD34 CD38
CD40 CD42 CD44 CD45 CD46 CD47 CD48
CD52 CD55 CD58 CD59 CD68 CD69 CD72
CD74 CD80 CD81 CD83 CD86 CD93 CD97
CD99 sCD100 CD109 CD146 CD147 CD163 CD169
CD177 CD200 CD209 CD226 CD244 CD248 CD274
CD276 CD281 CD282 CD283 CD284 CD286 CD288
CD289 CD320

Matrix Metalloproteinases

Matrix metalloproteinases (MMPs, also called matrixins) are zinc-dependent proteolytic enzymes. They can degrade various proteins in extracellular matrix (ECM). MMPs play an important role in many biological processes and diseases, e.g. embryogenesis, normal tissue remodeling, wound healing, angiogenesis, atherosclerosis, arthritis, cancer and tissue ulceration etc.

MMP-1 MMP-2 MMP-3 MMP-7 MMP-8 MMP-9 MMP-10
MMP-11 MMP-12 MMP-13 MMP-14 MMP-15 MMP-16 MMP-17
MMP-19 MMP-24 MMP-25 MMP-26 MMP-28

Growth Factors

Growth factors are polypeptide substances which regulate multiple effects (e.g. cell growth and other cell functions) via high affinity and specific-binding with cell membrane receptor. Usually, growth factors are secreted by normal cells without drug toxicity and immune reaction. During the research on physiological action, some of them are applied in clinical treatment. IL-2 has been used for cancer treatment and the effects on kidney cancer and melanoma are obvious. It's also used as immunomodulator for autoimmune diseases. IL-3 is applied in the treatment of bone marrow failure and platelet deficiency. Epidermal growth factors are applied in human burn, trauma, diabetes skin ulce, bedsore, varicose skin ulce and corneal injury etc. They can promote wound healing.

EGF FGF1 FGF2 FGF4 FGF5 FGF6 FGF7
FGF8 FGF9 FGF10 FGF15 FGF17 FGF18 FGF19
FGF20 FGF21 FGF22 FGF23 PDGF PDGFA PDGFAA
PDGFAB PDGFB PDGFBB PDGFC PDGFD TGF-α TGF-β1
TGF-β2 TGF-β3 VEGF VEGF165 VEGF-B VEGF-C VEGF-D

Chemokines

Chemokines are small cytokines or signaling proteins secreted by cells. They can induce chemotaxis of nearby reactive cells. Chemokines play a key role in chemotactic migration of cells. Cells migrate to the source of chemokines along the signal of increased concentration of chemokines.

CCL1 CCL2 CCL3 CCL4 CCL6 CCL7 CCL8
CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16
CCL17 CCL18 CCL19 CCL20 CCL22 CCL23 CCL24
CCL25 CCL26 CCL27 CCL28 CXCL1 CXCL2 CXCL3
CXCL5 CXCL6 CXCL7 CXCL9 CXCL10 CXCL11 CXCL13
CXCL14 CXCL16 CX3CL1

Colony-stimulating Factors

During the in vitro research on hematopoietic cells, some cytokines can stimulate different kinds of hematopoietic cells to form cell colony in semi-solid medium and are named as colony-stimulating factors. These factors can stimulate proliferation and differentiation of granulocyte metrocyte, and also enhance the function of mature granulocytes. They paly an important role in immunologic process of non-specific cells resistant to infection. When pyogenic bacteria or its the toxin invade into human body, G-CSF rapidly increases in the serum or body fluids. After the infection is controlled, G-CSF deceases to normal level. So the positive G-CSF indicates bacterial infection.

EPO G-CSF GM-CSF MCSF SCF TPO LIF

Interferons

Interferons are glycoproteins with high specificity. So interferons of animals are invalid for human. Interferons have the effect of anti-virus and tumor, inhibit cell proliferation and regulate immunity.

IFN-α IFN-β IFN-γ IFN-α2 IFN-α4 IFN-α6 IFN-α7
IFNA8 IFNE IFNW1 IFNA1/13 IFNA10 IFNA14 IFNA21

Tumor Necrosis Factors

TNF-α is derived from monocytes and phagocytes. TNF-β is derived from T lymphocytes. Although their structures are different, the biological activity is similar. They can not only cause bleeding, necrosis, and killing of tumor tissues, including inflammatory response effect against infection, but also affect regulation and induction of immune cells.

TNF-α TNF-β

Hot Research Topics for Cytokines

Proinflammatory and Anti Inflammatory Cytokines

 

Role of TNF Alpha in Rheumatoid Arthritis

 

 

 

Cytokines in Immunology

 

Role of Tnf Alpha in Cancer

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