SARS-CoV-2

SARS-CoV-2

2019 novel coronavirus is also called 2019-nCoV, SARS-CoV-2 and SARS-CoV2. SARS-CoV-2 and SARS-CoV belong to the same family with differences. Gene is single-stranded RNA. SARS-CoV-2 mainly consists of four structural proteins: spike glycoprotein (S), envelope proteins(E), membrane proteins(M), and nucleocapsid proteins(N).

Spike proteins(including 2 subunits: S1 and S2) are the most important pathogenic proteins. Binding to transmembrane receptor proteins ACE2 on human cell membrane helps to enter the cell. The spike protein is very large and can be divided into two parts: S1 contains receptor binding domain(RBD) which recognizes cell receptors. S2 contains basic components required for membrane fusion process. Current research focuses on S1-RBD protein, which is the target of antibody drugs.

Pathogenesis

SARS-CoV-2 binds to ACE2 receptor on host cell surface by the spike protein. After entering cells, spike proteins are cleaved into two subunits: S1 and S2. S1 is responsible for receptor binding. S2 helps the virus fuse with the cell membrane and promotes the virus to enter the cell. RNA genome of the virus encodes several functional proteins, and is responsible for the replication, assembly, and release of the virus by maintaining the transmission and pathogenicity in the host. The virus is transmitted by droplets, air and touching. Asymptomatic or mildly infected individuals can also transmit the virus. SARS-CoV-2 enters the cell by binding to ACE2 receptor on host cell surface, and replicates by host mechanism to cause the virus spread. Overreaction of immune system may cause cytokine storm, resulting in severe symptoms like lung injury and acute respiratory distress syndrome (ARDS) etc. The virus can also cause thrombosis and increase the risk of cardio-cerebro vascular complications.

SARS-CoV-2

FineTest Products

Nucleic acid and protein capsid are the most important components of the virus. Nucleic acid is responsible for reproduction of hereditary substance. Protein capsid protects hereditary substance. SARS-CoV-2 is named for the shape of its capsid. The research shows the spike glycoprotein mainly causes the binding to relevant receptors in human cells. Thus, it's the key target of neutralizing antibodies(nAbs), and also plays an important role in the treatment and vaccine design.

Recommended Products

Proteins:
Cat.No Product Name Host Expression Region Tag
P3302 Recombinant S1 Subunit[Omicron B.1.1.529] HEK293 cells 16-685 C-terminal His Tag
P3018 Recombinant SARS-CoV-2 Spike Glycoprotein HEK293 cells 16-1213 C-terminal His-Avi Tag
P3006 Recombinant SARS-CoV-2 Spike Glycoprotein RBD HEK293 cells 315-535 C-terminal His Tag
P8823 Recombinant SARS-CoV-2 Spike Glycoprotein S1 HEK293 cells 16-685 C-terminal His Tag
P8790 Recombinant SARS-CoV-2 Spike Glycoprotein S2 HEK293 cells 686-1213 C-terminal rbFc-His Tag
P8947 Recombinant ORF8 HEK293 cells 16-121 C-terminal His Tag
P3003 Recombinant SARS-CoV-2 Nucleoprotein E.Coli 1-419 N-terminal His Tag
P2908 Recombinant SARS-CoV-2 Nucleoprotein [Delta B.1.617.2] E.Coli 1-419 N-terminal His Tag
P3123 Recombinant SARS-CoV-2 Nucleoprotein [Omicron B.1.1.529] E.Coli 1-419 N-terminal His Tag
P1023 Recombinant SARS-CoV-2 Nucleoprotein-N1 E.Coli 1-182 N-terminal His Tag
P1024 Recombinant SARS-CoV-2 Nucleoprotein-N2 E.Coli 227-419 N-terminal His Tag
Antibodies:
Cat.No Product Name Host Clonality Reactivity Tested Applications
FNab10307 Mouse Anti-Human IgG1 Mouse monoclonal Human Colloidal Gold-Based, ELISA, IHC, WB
FNab10306 Mouse Anti-Human IgM Mouse monoclonal Human Colloidal Gold-Based, ELISA, IHC, WB
FNab10309 SARS-CoV-2 N protein antibody Mouse monoclonal 2019 nCOV ELISA, WB, Colloidal Gold-Based
FNab10600 SARS-CoV-2 N protein antibody Rabbit monoclonal 2019 nCOV ELISA, WB, Colloidal Gold-Based
FNab10601 SARS-CoV-2 N protein antibody Rabbit monoclonal 2019 nCOV ELISA, WB, Colloidal Gold-Based
ELISA Kits:
Species Cat.No Product Name Sensitivity Range
Human EH5032 Human Anti SARS-CoV-2 (COVID) Spike RBD Alpha B.1.1.7 Variant(UK Variant) IgA ELISA Kit 0.469ng/ml 0.781-50ng/ml
Human EH5030 Human Anti SARS-CoV-2 (COVID) Spike RBD Alpha B.1.1.7 Variant(UK Variant) IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Human EH5031 Human Anti SARS-CoV-2 (COVID) Spike RBD Alpha B.1.1.7 Variant(UK Variant) IgM ELISA Kit 0.469ng/ml 0.781-50ng/ml
Human EH4950 Human Anti-2019 nCoV(N+S) IgA ELISA Kit 0.234ng/ml 0.391-25ng/ml
Human EH4943 Human anti-2019 nCoV(N+S) IgG ELISA Kit 2.344ng/ml 3.906-250ng/ml
Human EH4944 Human anti-2019 nCoV(N+S) IgM ELISA Kit 0.469ng/ml 0.781-50ng/ml
Human EH4956 Human Anti-2019 nCoV(S) IgA ELISA Kit 0.234ng/ml 0.391-25ng/ml
Human EH4951 Human Anti-SARS-CoV2(S)IgM ELISA Kit 0.469ng/ml 0.781-50ng/ml
Human EH4397 Human anti-SARS-CoV2(N) IgG ELISA Kit 2.344ng/ml 3.906-250ng/ml
Human EH4940 Human anti-SARS-CoV2(N) IgM ELISA Kit 0.469ng/ml 0.781-50ng/ml
Human EH4981 Human anti-SARS-CoV2(S) IgG ELISA Kit 2.344ng/ml 3.906-250ng/ml
Human EH5001 Human anti-SARS-CoV2(S-RBD) (Omicron,B.1.1.529) IgM ELISA Kit 0.938ng/ml 1.563-100ng/ml
Human EH5002 Human anti-SARS-CoV2(S-RBD) (Omicron,B.1.1.529) IgA ELISA Kit 0.938ng/ml 1.563-100ng/ml
Human EH5009 Human anti-SARS-CoV2(S-RBD) (Omicron,BA.5.2) IgA ELISA Kit 0.938ng/ml 1.563-100ng/ml
Human EH5007 Human anti-SARS-CoV2(S-RBD) (Omicron,BA.5.2) IgG ELISA Kit 2.34ng/ml 3.9-250ng/ml
Human EH5008 Human anti-SARS-CoV2(S-RBD) (Omicron,BA.5.2) IgM ELISA Kit 0.938ng/ml 1.563-100ng/ml
Human EH4971 Human anti-SARS-CoV2(S-RBD)(Omicron,B.1.1.529) IgG ELISA Kit 2.34ng/ml 3.9-250ng/ml
Human EH4395 Human anti-2019 nCoV(N) IgG ELISA Kit Qualitative Qualitative
Human EH4396 Human anti-2019 nCoV(N) IgM ELISA Kit Qualitative Qualitative
Human EH4946 Human Anti-2019 nCoV(N+S) IgG ELISA Kit Qualitative Qualitative
Human EH4948 Human Anti-2019 nCoV(N+S) IgM ELISA Kit Qualitative Qualitative
Human EH4941 Human anti-2019 nCoV(S) IgG ELISA Kit Qualitative Qualitative
Human EH4942 Human anti-2019 nCoV(S) IgM ELISA Kit Qualitative Qualitative
Mouse EM1959 Mouse Anti-2019 nCoV(N) IgG ELISA Kit 2.34ng/ml 3.9-250ng/ml
Mouse EM1906 Mouse Anti-2019 nCoV(S)IgA ELISA Kit 0.094ng/ml 0.156-10ng/ml
Mouse EM1907 Mouse Anti-2019 nCoV(S)IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Mouse EM1908 Mouse Anti-2019 nCoV(S)IgM ELISA Kit 0.469ng/ml 0.781-50ng/ml
Mouse EM2059 Mouse anti-SARS-CoV2(S-RBD)(Delta B.1.617.2)IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Mouse EM1970 Mouse Anti SARS-CoV-2(COVID) Spike RBD Alpha B.1.1.7 Variant(UK Variant) IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Mouse EM1971 Mouse Anti SARS-CoV-2(COVID) Spike RBD Alpha B.1.1.7 Variant( UK Variant) IgM ELISA Kit 0.469ng/ml 0.781-50ng/ml
Mouse EM2121 Mouse anti-SARS-CoV2(S-RBD)(XBB.1)IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Mouse EM2037 Mouse anti-SARS-CoV2(S-RBD)(Omicron,B.1.1.529) IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Mouse EM1961 Mouse Anti-2019 nCoV(S) IgG ELISA Kit Qualitative Qualitative
Mouse EM1962 Mouse Anti-2019 nCoV(N) IgG ELISA Kit Qualitative Qualitative
Hamster EHA0024 Hamster anti- SARS-CoV-2(N protein) IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Hamster EHA0026 Hamster anti- SARS-CoV-2(RBD) IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Hamster EHA0025 Hamster anti- SARS-CoV-2 (S protein) IgG ELISA Kit 0.938ng/ml 1.563-100ng/ml
Porcine EP0379 Porcine anti-SARS-CoV2 (S-RBD) (Delta B.1.617.2)antibody ELISA Kit 1.875ng/ml 3.125-200ng/ml
COVID-19 AQ-U3128 COVID-19 Spike Protein (RBD) Accquant ELISA Kit 390fg/ml 0.78-50pg/ml
Universal EU3125 Anti-2019 nCoV(N) Ig ELISA Kit Qualitative Qualitative