
PD-1 and PD-L1 in Cancer
Abstract: Programmed cell death-1(PD-1) and its ligand 1(PD-L1) are important immune checkpoints regulating adaptive immune response. PD-1 consists of 288 amino acids and is mainly expressed in activated T cell, B cell and tumor infiltrating lymphocyte. PD-L1 consists of 290 amino acids and is widely distributed in tumor and antigen presenting cells. They interact with …