Products
Beclin 1 antibody
References
1
Category:
Synonyms: | ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30 antibody | ||
Catalogue No.: | FNab10873 | Reactivity: | Human, Mouse, Rat |
Host: | Mouse | Tested Application: | ELISA, IHC, WB |
Clonality: | monoclonal | Isotype: | IgG1 |
- SPECIFICATIONS
- CITATIONS
- Product Name
- Beclin 1 antibody
- Catalogue No.
- FNab10873
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 1G5
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- beclin 1, autophagy related
- Alternative Names
- ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30 antibody
- UniProt ID
- Q14457
- Observed MW
- 60 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500 - 1:5000; IHC: 1:50 - 1:200
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab10873(Beclin 1 Antibody) at dilution of 1:3000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab10873(Beclin 1 antibody) at dilution of 1:100
- Background
- Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
IF: 5.2
- Journal:
- Cancers
- Author:
- Group of Experimental Biotherapy and Diagnostics, Institute for Regenerative Medicine, World-Class Research Centre “Digital Biodesign and Personalized Healthcare”, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia
- Cited Date:
- 2023-11-10
- Product: