Products
BECN1 antibody
- Product Name
- BECN1 antibody
- Catalogue No.
- FNab10873
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 1G5
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- beclin 1, autophagy related
- Alternative Names
- Beclin-1|Coiled-coil myosin-like BCL2-interacting protein|Protein GT197|Beclin-1-C 35 kDa|Beclin-1-C 37 kDa|BECN1|GT197 antibody
- UniProt ID
- Q14457
- Observed MW
- 60 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500 - 1:5000; IHC: 1:50 - 1:200
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab10873(Beclin 1 Antibody) at dilution of 1:3000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab10873(Beclin 1 antibody) at dilution of 1:100
- Background
- Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.