Products
BAX antibody
- Product Name
- BAX antibody
- Catalogue No.
- FNab00810
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- BCL2-associated X protein
- Alternative Names
- BCL2L4 antibody, Apoptosis regulator BAX antibody, BAX antibody
- UniProt ID
- Q07812
- Observed MW
- 21 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP, FC
- Recommended dilution
- WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00810(BAX antibody) at dilution of 1:1000
IP Result of anti-BAX (IP: FNab00810, 3ug; Detection: FNab00810 1:2000) with Raji cells lysate 3500ug.
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab00810(BAX Antibody) at dilution of 1:50
- Background
- BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).
