Products
Cyclin D1 antibody
- Product Name
- Cyclin D1 antibody
- Catalogue No.
- FNab10467
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- cyclin D1
- Alternative Names
- B cell lymphoma 1 protein antibody, CCND1 antibody, cyclin D1 antibody, D11S287E antibody, G1/S specific cyclin D1 antibody, PRAD1 antibody, PRAD1 oncogene antibody, U21B31 antibody
- UniProt ID
- P24385
- Observed MW
- 36 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
various lysates were subjected to SDS PAGE followed by western blot with FNab10467(Cyclin D1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human esophagus using FNab10467(cyclin D1 antibody) at dilution of 1:100
- Background
- CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.
