Products
SIRT1 antibody
- Product Name
- SIRT1 antibody
- Catalogue No.
- FNab10371
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- sirtuin (silent mating type information regulation 2 homolog) 1
- Alternative Names
- hSIR2 antibody, hSIRT1 antibody, SIR2 like protein 1 antibody, SIR2L1 antibody, SIRT1 antibody
- UniProt ID
- Q96EB6
- Observed MW
- 130 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
Validated Images
Various lysates were subjected to SDS PAGE followed by western blot with FNa10371( SIRT1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab10371( SIRT1 Antibody) at dilution of 1:100
Immunofluorescent analysis of (10% Formaldehyde) fixed HeLa cells using FNab10371 (SIRT1 antibody) at dilution of 1:50 and FITC-conjugated Goat Anti-Rabbit IgG(H+L).
- Background
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
