Products

anti- P16-INK4A antibody

FNab06064 Catalogue No.
Synonyms
ARF, CDKN2A, CDK4 inhibitor p16 INK4, CDK4 inhibitor p16INK4, CDK4I, CDKN2, CDKN2A, CMM2, INK4, INK4a, MLM, MTS 1, MTS1, Multiple tumor suppressor 1, p14, p14ARF, P16, p16 INK4, p16 INK4a, p16INK4, p16INK4a, P19, TP16
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IF, IP, IHC, FC
Product Information
Product Name
anti- P16-INK4A antibody
Catalogue No.
FNab06064
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14 (ARF) or p19 (ARF) . FNab06064 reacted with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.
Immunogen Information
Immunogen
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Synonyms
ARF, CDKN2A, CDK4 inhibitor p16 INK4, CDK4 inhibitor p16INK4, CDK4I, CDKN2, CDKN2A, CMM2, INK4, INK4a, MLM, MTS 1, MTS1, Multiple tumor suppressor 1, p14, p14ARF, P16, p16 INK4, p16 INK4a, p16INK4, p16INK4a, P19, TP16
Observed MW
16kDa
Application
Tested Application
ELISA, WB, IF, IP, IHC, FC
Recommended dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500; IF: 1:20-1:200
Uniprot information
UniProt ID
P42771
Images
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab06064 (P16-INK4A Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer (pH9) .
IP Result of anti-P16 (IP: FNab06064, 4ug; Detection: FNab06064 1:1000) with HEK-293 cells lysate 4500ug.
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06064 (P16 antibody) at dilution of 1:1000