Products
ARG1 antibody
- Product Name
- ARG1 antibody
- Catalogue No.
- FNab04800
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- arginase, liver
- Alternative Names
- Arginase-1|Liver-type arginase|Type I arginase|ARG1 antibody
- UniProt ID
- P05089
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:1000-1:5000; IHC: 1:100-1:400; IF: 1:20-1:200
Validated Images
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab04800(ARG1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab04800(ARG1 Antibody) at dilution of 1:200
Immunofluorescent analysis of HepG2 cells using FNab04800( ARG1 Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical?marker?of hepatocellular differentiation in fine needle aspiration cytology and a marker?of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406).
