Products
P16-INK4A antibody
- Product Name
- P16-INK4A antibody
- Catalogue No.
- FNab06064
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- cyclin-dependent kinase inhibitor 2A(melanoma, p16, inhibits CDK4)
- Alternative Names
- ARF antibody, CDKN2A antibody, CDK4 inhibitor p16 INK4 antibody, CDK4 inhibitor p16INK4 antibody, CDK4I antibody, CDKN2 antibody, CDKN2A antibody, CMM2 antibody, INK4 antibody, INK4a antibody, MLM antibody, MTS 1 antibody, MTS1 antibody, Multiple tumor suppressor 1 antibody, p14 antibody, p14ARF antibody, P16 antibody, p16 INK4 antibody, p16 INK4a antibody, p16INK4 antibody, p16INK4a antibody, P19 antibody, TP16 antibody
- UniProt ID
- P42771
- Observed MW
- 16-18 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP, IHC, FC
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500; IF: 1:20-1:200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06064(P16 antibody) at dilution of 1:1000
IP Result of anti-P16 (IP: FNab06064, 4ug; Detection: FNab06064 1:1000) with HEK-293 cells lysate 4500ug.
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab06064(P16-INK4A Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14(ARF) or p19(ARF). FNab06064 reacted with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.
