Structure of 2019-nCoV
2019 novel coronavirus is also called 2019-nCoV, SARS-CoV-2, SARS-CoV2. Novel coronavirus and SARS coronavirus (SARS-CoV) are of the same class, but not the same species, with single-stranded RNA genes.
4 types of main Structure protein:
Spike Surface Glycoprotein (S)
Envelope Protein (E)
Matrix Protein (M)
Nucleocapsid Protein (N)
2019-nCoV related protein
S pike protein is big and it consists of 2 subunits, S1 and S2. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. Recent research mainly focuses on S1-RBD protein, which is target point for antibody drugs.
N protein and viral genome RNA entwined each other to form viral nucleocapsid, which plays an important role in the synthesis of viral RNA. At the same time, N protein is relatively conservative, which accounts for the largest proportion in the Structure protein of the virus. At the early stage of infection, the organism can produce high-level antibodies against N protein. Therefore, N protein can be used to establish a rapid 2019-ncov serum antibody detection method.
Latest Launched FineTest N protein Related Products
|Catalog No.||Commodity Name|
|P3003||Recombinant 2019-nCov N protein|
|FNab10308||Anti- 2019-nCov N protein antibody (Clone#1G5) (N protein monoclonal antibody)|
|FNab10309||Anti- 2019-nCov N protein antibody (Clone#3G6) (N protein monoclonal antibody)|
|EH4395||Human anti-2019-nCoV(N) IgG ELISA Kit (Qualitative)|
|EH4396||Human anti-2019-nCoV(N) IgM ELISA Kit (Qualitative)|
|EH4397||Human anti-SARS-CoV2 IgG ELISA Kit (Qualitative)|
|EH4940||Human anti-SARS-CoV2 IgM ELISA Kit (Quantitative)|
|EU3124||COVID-19 nucleoprotein ELISA Kit (Detection virus N protein, Quantitative)|
|EU3125||anti-2019-nCoV(N)Ig ELISA Kit (for detection of total Ig for virous of species, Qualitative)|
2019-nCov Nucleic Acid Testing Kit
Qualitative detecting of both ORF1ab and N gene of 2019-nCoV by fluorescent PCR.
N protein gene is relatively conservative, and will cross with other virus genes, which may easily lead to misdiagnosis. While ORF1ab gene has high specificity, detecting both N protein and ORF1ab gene can be more effectively and could avoid misdiagnosis.
Nucleic Acid Detection takes an average of 2-3 hours, and the experiment process requires automatic nucleic acid extraction instrument and fluorescence quantitative PCR instrument.
|FineTest 2019-nCoV Nucleic Acid Detection Kit|
|Catalog No.||Commodity Name||Size|
|EH4934||2019-Novel Coronavirus (2019-nCoV) RT-qPCR Detection Kit||50T/Kit|
2019-nCoV Rapid Detection Strips
Using colloidal gold immunochromatography detects both IgG and IgM antibodies in (finger blood, serum, plasma) samples.
IgM + IgG joint detection-monitoring of 2019-nCoV infections throughout the cycle (early, middle and late)
• IgM and IgG are two different antibodies produced by the human body against pathogenic microorganisms (including viruses).
• IgM is the first antibody that appears after infection. The 2019-nCoV infection peaks after 3-7 days, and gradually decreases thereafter. IgM Detection can indicate early infection.
• IgG is an antibody produced in large quantities when B cells enter the lymph nodes and differentiate into plasma cells in the middle and late stage of infection. IgG detection indicates the recovery after infection or infection is taking place.
|Fine Test 2019-nCoV Rapid Detection Strips|
|Catalog No.||Commodity Name|
|EH4933||2019-nCoV IgM/IgG Antibody Colloidal Gold Assay Kit|