Products
WWP1 antibody
- Product Name
- WWP1 antibody
- Catalogue No.
- FNab09534
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- WW domain containing E3 ubiquitin protein ligase 1
- Alternative Names
- AIP5 antibody, DKFZp434D2111 antibody, hSDRP1 antibody, Tiul1 antibody, WW domain containing protein 1 antibody, WWP1 antibody
- UniProt ID
- Q9H0M0
- Observed MW
- 90-110 kDa
Application
- Tested Applications
- ELISA, WB, IP, IHC, IF
- Recommended dilution
- WB: 1:200-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab09534(WWP1 antibody) at dilution of 1:300
IP Result of anti-WWP1 (IP:FNab09534, 4ug; Detection:FNab09534 1:300) with PC-3 cells lysate 1040ug.
Immunofluorescent analysis of PC-3 cells using FNab09534 ( WWP1 Antibody) at dilution of 1:50
- Background
- E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
