Products

VEGF antibody

Synonyms:L VEGFA antibody, MVCD1 antibody, Vascular permeability factor antibody, VEGF antibody, VEGF A antibody, VEGFA antibody, VPF antibody
Catalogue No.:FNab09391Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, IHC, IF, WB
Clonality:polyclonalIsotype:IgG
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Product Name
VEGF antibody
Catalogue No.
FNab09391
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
vascular endothelial growth factor A
Alternative Names
L VEGFA antibody, MVCD1 antibody, Vascular permeability factor antibody, VEGF antibody, VEGF A antibody, VEGFA antibody, VPF antibody
UniProt ID
P15692
Observed MW
15-27kDa, 34-45kDa
Application
Tested Applications
ELISA, IHC, IF, WB
Recommended dilution
WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:50-1:500
Validated Images
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab09391(VEGFA antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab09391(VEGFA Antibody) at dilution of 1:200
Immunofluorescent analysis of HepG2 cells, using VEGFA antibody (FNab09391) at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Background
VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010).