anti- USP33 antibody
FNab09326
Catalogue No.
- Synonyms:
- Deubiquitinating enzyme 33, hVDU1, KIAA1097, Ubiquitin thiolesterase 33, USP33, VDU1
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Isotype:
- IgG
- Tested Application:
- ELISA, WB, IHC
Product Information
- Product Name
- anti- USP33 antibody
- Catalogue No.
- FNab09326
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Host
- Rabbit
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
- Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor(GPCR) signaling by mediating the deubiquitination of beta-arrestins(ARRB1 and ARRB2) and beta-2 adrenergic receptor(ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
Immunogen Information
- Immunogen
- ubiquitin specific peptidase 33
- Synonyms
- Deubiquitinating enzyme 33, hVDU1, KIAA1097, Ubiquitin thiolesterase 33, USP33, VDU1
- Observed MW
- 107 kDa
Application
- Tested Application
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1：20-1：200
Uniprot information
- UniProt ID
- Q8TEY7
Images
- Image 1
-
Immunohistochemistry of paraffin-embedded human kidney slide using FNab09326(USP33 Antibody) at dilution of 1:50
- Image 4
-
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09326(USP33 antibody) at dilution of 1:300