Products

USP21 antibody

Synonyms:Deubiquitinating enzyme 21 antibody, Ubiquitin thiolesterase 21 antibody, USP16 antibody, USP21 antibody, USP23 antibody
Catalogue No.:FNab09318Reativity:Human
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
USP21 antibody
Catalogue No.
FNab09318
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
ubiquitin specific peptidase 21
Alternative Names
Deubiquitinating enzyme 21 antibody, Ubiquitin thiolesterase 21 antibody, USP16 antibody, USP21 antibody, USP23 antibody
UniProt ID
Q9UK80
Observed MW
63 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
RAW 264.7 cells were subjected to SDS PAGE followed by western blot with FNab09318(USP21 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab09318(USP21 Antibody) at dilution of 1:50
Background
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di-and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination(By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates(PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization(PubMed:26100909).