Products
UPF1 antibody
- Product Name
- UPF1 antibody
- Catalogue No.
- FNab09270
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- UPF1 regulator of nonsense transcripts homolog (yeast)
- Alternative Names
- Regulator of nonsense transcripts 1|ATP-dependent helicase RENT1|Nonsense mRNA reducing factor 1 (NORF1)|Up-frameshift suppressor 1 homolog (hUpf1)|UPF1|KIAA0221|RENT1 antibody
- UniProt ID
- Q92900
- Observed MW
- 124 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09270(UPF1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human kidney slide using FNab09270( UPF1 Antibody) at dilution of 1:50
- Background
- This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
