Products
SMARCA4 antibody
- Product Name
- SMARCA4 antibody
- Catalogue No.
- FNab08005
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
- Alternative Names
- ATP dependent helicase SMARCA4 antibody, BAF190 antibody, BAF190A antibody, BRG1 antibody, BRG1 associated factor 190A antibody, FLJ39786 antibody, hSNF2b antibody, Protein brahma homolog 1 antibody, Protein BRG 1 antibody, SMARCA4 antibody, SNF2 antibody, SNF2 BETA antibody, SNF2B antibody, SNF2L4 antibody, SNF2LB antibody, SWI2 antibody, Transcription activator BRG1 antibody
- UniProt ID
- P51532
- Observed MW
- 185 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP:1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08005(SMARCA4 antibody) at dilution of 1:800
IP Result of anti-SMARCA4 (IP: FNab08005, 5ug; Detection: FNab08005 1:1000) with HeLa cells lysate 2500ug
Immunohistochemistry of paraffin-embedded human lung cancer using FNab08005(SMARCA4 antibody) at dilution of 1:100
- Background
- SMARCA4, also named as BAF190A, BRG1, SNF2B and SNF2L4, belongs to the SNF2/RAD54 helicase family. SMARCA4 is a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It is a component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. It is also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor(VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
