Products
NEDD4L antibody
- Product Name
- NEDD4L antibody
- Catalogue No.
- FNab05646
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- neural precursor cell expressed, developmentally down-regulated 4-like
- Alternative Names
- E3 ubiquitin-protein ligase NEDD4-like|HECT-type E3 ubiquitin transferase NED4L|NEDD4.2|Nedd4-2|NEDD4L|KIAA0439|NEDL3 antibody
- UniProt ID
- Q96PU5
- Observed MW
- 113 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
K-562 cells were subjected to SDS PAGE followed by western blot with FNab05646(NEDD4L antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human prostate using FNab05646(NEDD4L antibody) at dilution of 1:200
- Background
- This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
