Products
MFN2 antibody
- Product Name
- MFN2 antibody
- Catalogue No.
- FNab05151
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- mitofusin 2
- Alternative Names
- CMT2A antibody, CMT2A2 antibody, CPRP1 antibody, HSG antibody, KIAA0214 antibody, MARF antibody, MFN2 antibody, Mitofusin 2 antibody, Transmembrane GTPase MFN2 antibody
- UniProt ID
- O95140
- Observed MW
- 86 kDa
Application
- Tested Applications
- ELISA, WB, IP, IHC
- Recommended dilution
- IP: 1:200-1:1000; WB: 1:200-1:1000; IHC: 1:50-1:500
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab05151(MFN2 antibody) at dilution of 1:500
IP result of anti-MFN2(IP:FNab05151, 4ug; Detection:FNab05151 1:300) with mouse kidney tissue lysate 3000 ug
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab05151(MFN2 Antibody) at dilution of 1:200
- Background
- Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy(mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response(UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
