Products
IL-10 antibody
- Product Name
- IL-10 antibody
- Catalogue No.
- FNab04211
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interleukin 10
- Alternative Names
- CSIF antibody, IL 10 antibody, IL10 antibody, IL-10 antibody, IL10A antibody, interleukin 10 antibody, TGIF antibody
- UniProt ID
- P22301
- Observed MW
- 21 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
Recombinant protein were subjected to SDS PAGE followed by western blot with FNab04211( IL10 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab04211( IL10 Antibody) at dilution of 1:100
- Background
- The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
