Products

HMGCR antibody

Synonyms:HMG CoA reductase antibody, HMGCR antibody, 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody, HMDH antibody
Catalogue No.:FNab03929Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
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Product Name
HMGCR antibody
Catalogue No.
FNab03929
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Alternative Names
HMG CoA reductase antibody, HMGCR antibody, 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody, HMDH antibody
UniProt ID
P04035
Observed MW
100 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab03929(HMGCR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab03929(HMGCR antibody) at dilution of 1:100
Background
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IF: 3.2
Journal:
Immunity, Inflammation and Disease
Author:
Department of Infectious Disease, The Affiliated People's Hospital of Ningbo University, Ningbo City, Zhejiang Province, China
Cited Date:
2023-08-25
Product: