Products
GNE antibody
- Product Name
- GNE antibody
- Catalogue No.
- FNab03544
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Alternative Names
- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase|UDP-GlcNAc-2-epimerase/ManAc kinase|GNE|GLCNE|IBM2 antibody
- UniProt ID
- Q9Y223
- Observed MW
- 70-120 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03544(GNE Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab03544(GNE Antibody) at dilution of 1:50
- Background
- The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
