A431 cells were subjected to SDS PAGE followed by western blot with FNab02123(CCNB2 antibody) at dilution of 1:1000
IP Result of anti-CCNB2 (IP: FNab02123, 4ug; Detection: FNab02123 1:1000) with A431 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab02123(CCNB2 Antibody) at dilution of 1:200
Background
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.