Products

CD44 antibody

Synonyms:LHR antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody
Catalogue No.:FNab01483Reativity:Human
Host:MouseTested Application:ELISA, WB, IHC, IF, FC
Clonality:monoclonalIsotype:IgG2a
  • SPECIFICATIONS
Product Name
CD44 antibody
Catalogue No.
FNab01483
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG2a
Clone ID
7D6
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
CD44 molecule(Indian blood group)
Alternative Names
LHR antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody
UniProt ID
P16070
Observed MW
80-95 kDa
Application
Tested Applications
ELISA, WB, IHC, IF, FC
Recommended dilution
WB: 1:500-1:5000; IHC: 1:50-1:200; IF: 1:10-1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01483(CD44 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer slide using FNab01483(CD44 Antibody) at dilution of 1:50
Background
Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).