Products
Alpha-2-macroglobulin antibody
- Product Name
- Alpha-2-macroglobulin antibody
- Catalogue No.
- FNab00341
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 6D0
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- alpha-2-macroglobulin
- Alternative Names
- A2M antibody, Alpha 2 M antibody, alpha 2 macroglobulin antibody, CPAMD5 antibody, DKFZp779B086 antibody, FWP007 antibody, S863 7 antibody, α-2M antibody
- UniProt ID
- P01023
- Observed MW
- 185 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:1000; IF: 1:50-1:500; IHC: 1:20-1:200
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00341(A2M antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver slide using FNab00341(A2M Antibody) at dilution of 1:50
- Background
- Alpha-2-macroglobulin, also known as α2-macroglobulin(α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.
