Products
NEIL1 antibody
- Product Name
- NEIL1 antibody
- Catalogue No.
- FNab10789
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- nei endonuclease VIII-like 1(E. coli)
- Alternative Names
- DNA glycosylase/AP lyase Neil1 antibody, Endonuclease 8 like 1 antibody, Endonuclease VIII like 1 antibody, FPG1 antibody, hFPG1 antibody, NEH1 antibody, Nei homolog 1 antibody, Nei like protein 1 antibody, NEI1 antibody, NEIL1 antibody
- UniProt ID
- Q96FI4
- Observed MW
- 44kd
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:1000
Validated Images
rat liver were subjected to SDS PAGE followed by western blot with FNab10789(NEIL1 antibody) at dilution of 1:500
- Background
- Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine(Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP(apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine(5hmC), suggesting that it acts as a specific reader of 5hmC.
