Products
WDFY3 antibody
- Product Name
- WDFY3 antibody
- Catalogue No.
- FNab09479
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- WD repeat and FYVE domain containing 3
- Alternative Names
- ALFY antibody, Autophagy linked FYVE protein antibody, KIAA0993 antibody, WDFY3 antibody, ZFYVE25 antibody
- UniProt ID
- Q8IZQ1
Application
- Tested Applications
- ELISA, IHC
- Recommended dilution
- IHC: 1:20-1:200
Validated Images
Immunohistochemical of paraffin-embedded human breast cancer using FNab09479(WDFY3 antibody) at dilution of 1:50
- Background
- Required for selective autophagy(aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies(p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
