Products
USP15 antibody
- Product Name
- USP15 antibody
- Catalogue No.
- FNab09311
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin specific peptidase 15
- Alternative Names
- Deubiquitinating enzyme 15 antibody, KIAA0529 antibody, Ubiquitin thiolesterase 15 antibody, Unph 2 antibody, UNPH4 antibody, USP15 antibody
- UniProt ID
- Q9Y4E8
- Observed MW
- 112 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab09311(USP15 Antibody) at dilution of 1:1000
IP Result of anti-USP15 (IP:FNab09311, 4ug; Detection:FNab09311 1:1000) with mouse brain tissue lysate 4000ug.
- Background
- Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs(SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes(PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B(PubMed:24526689). Acts as an associated component of COP9 signalosome complex(CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
