human brain tissue were subjected to SDS PAGE followed by western blot with FNab09143(UBA2 antibody) at dilution of 1:500
Background
The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.