Products
SNAI1 antibody
- Product Name
- SNAI1 antibody
- Catalogue No.
- FNab08051
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- snail homolog 1(Drosophila)
- Alternative Names
- Protein sna antibody, Protein snail homolog 1 antibody, SLUGH2 antibody, SNA antibody, SNAH antibody, SNAI1 antibody, snail homolog 1(Drosophila) antibody, SNAIL1 antibody, Zinc finger protein SNAI1 antibody
- UniProt ID
- O95863
- Observed MW
- 29KD
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:50-1:500
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08051(SNAI1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08051(SNAI1 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- Involved in induction of the epithelial to mesenchymal transition(EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate(TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
