Products
SMCR7L antibody
- Product Name
- SMCR7L antibody
- Catalogue No.
- FNab08023
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Smith-Magenis syndrome chromosome region, candidate 7-like
- Alternative Names
- dJ1104E15.3 antibody, FLJ20232 antibody, HSU79252 antibody, MID51 antibody, MIEF1 antibody, SMCR7L antibody
- UniProt ID
- Q9NQG6
- Observed MW
- 49 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000; IF: 1:10-1:100
Validated Images
HT-1080 cells were subjected to SDS PAGE followed by western blot with FNab08023(SMCR7L antibody) at dilution of 1:400
IP Result of anti-SMCR7L/MID51 (IP:FNab08023, 3ug; Detection:FNab08023 1:1000) with RAW 264.7 cells lysate 2400ug.
- Background
- Human SMCR7L gene encodes, MID51, the mitochondrial dynamic protein of 51 kDa(also called mitochondrial elongation factor 1, MIEF1). MID51 is a single-pass membrane protein anchored to the mitochondrial outer membrane and regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposing processes: fusion and fission. Elevated MID51 levels induce extensive mitochondrial fusion, whereas depletion of MID51 causes mitochondrial fragmentation. MID51 interacts with and recruits Drp1 to mitochondria, suggesting a critical role of MID51 in regulation of mitochondrial fusion-fission machinery in vertebrates.
