Products
SLC12A5-Specific antibody
- Product Name
- SLC12A5-Specific antibody
- Catalogue No.
- FNab07908
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- solute carrier family 12(potassium-chloride transporter), member 5
- Alternative Names
- hKCC2 antibody, K Cl cotransporter 2 antibody, KCC2 antibody, KIAA1176 antibody, Neuronal K Cl cotransporter antibody, SLC12A5 antibody
- UniProt ID
- Q9H2X9
- Observed MW
- 126 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab07908(SLC12A5-Specific antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human brain using FNab07908(SLC12A5-Specific antibody) at dilution of 1:100
- Background
- KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl-cotransporter that is essential for Cl-homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect ~130 kda monomer and ~250 kDa dimer of KKC2 in brain lysate.
