Products
RIP3 antibody
- Product Name
- RIP3 antibody
- Catalogue No.
- FNab07312
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- receptor-interacting serine-threonine kinase 3
- Alternative Names
- Receptor interacting protein 3 antibody, RIP 3 antibody, RIP like protein kinase 3 antibody, RIP3 antibody, RIPK3 antibody
- UniProt ID
- Q9Y572
- Observed MW
- 57 kDa
Application
- Tested Applications
- ELISA, IP, WB,IHC
- Recommended dilution
- WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07312(RIP3 antibody) at dilution of 1:500
IP Result of anti-RIP3 (IP: FNab07312, 3ug; Detection: FNab07312 1:300) with SW 1990 cells lysate 3000ug.
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab07312(RIP3 antibody) at dilution of 1:200
- Background
- Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
