Products
REDD1 specific antibody
- Product Name
- REDD1 specific antibody
- Catalogue No.
- FNab07228
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- DNA-damage-inducible transcript 4
- Alternative Names
- HIF-1 responsive protein RTP801 antibody, Protein regulated in development and DNA damage response 1 antibody, REDD-1 antibody, REDD1 antibody, RTP801 antibody, DDIT4 antibody
- UniProt ID
- Q9NX09
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, IHC, IP, WB
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200
Validated Images
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab07228(REDD1 antibody) at dilution of 1:1000
IP Result of anti-REDD1 specific (IP:FNab07228, 3ug; Detection:FNab07228 1:500) with MCF-7 cells lysate 2500ug.
Immunohistochemistry of paraffin-embedded human breast cancer using FNab07228(REDD1 antibody) at dilution of 1:100
- Background
- REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function：Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1(mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes(By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication(By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.
