Products
phospho-TDP43 (409/410) antibody
- Product Name
- phospho-TDP43 (409/410) antibody
- Catalogue No.
- FNab06401
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- TAR DNA binding protein
- Alternative Names
- phospho TDP43 antibody, phospho(409/410)-TDP43 antibody, TARDBP antibody, TDP43 antibody
- UniProt ID
- Q13148
- Observed MW
- 48 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:2000
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab06401(phospho(409/410)-TDP43 antibody) at dilution of 1:1000
- Background
- TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25kDa form, in ubiquitin-containing inclusion bodies. In pathological tissues, TDP-43 is highly phosphorylated and Ser409/410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409/410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa.
