K-562 cells were subjected to SDS PAGE followed by western blot with FNab05921(NUP153 antibody) at dilution of 1:500
IP Result of anti-NUP153 (IP:FNab05921, 4ug; Detection:FNab05921 1:500) with K-562 cells lysate 3600ug.
Background
Component of the nuclear pore complex(NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element(CTE) in a NXF1-and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex(NPC).