Products
MYO9B antibody
- Product Name
- MYO9B antibody
- Catalogue No.
- FNab05509
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- myosin IXB
- Alternative Names
- MYR5 antibody
- UniProt ID
- Q13459
- Observed MW
- 230-250kd
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000
Validated Images
mouse thymus tissue were subjected to SDS PAGE followed by western blot with FNab05509( MYO9B Antibody) at dilution of 1:600
IP Result of anti-MYO9B (IP:FNab05509, 5ug; Detection:FNab05509 1:500) with HepG2 cells lysate 2800ug.
- Background
- Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions(PubMed:9490638). Also acts as a GTPase activator for RHOA(PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA(PubMed:26529257).
