Products
MMP12 antibody
- Product Name
- MMP12 antibody
- Catalogue No.
- FNab05234
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- matrix metallopeptidase 12(macrophage elastase)
- Alternative Names
- HME antibody, Macrophage elastase antibody, Macrophage metalloelastase antibody, Matrix metalloproteinase 12 antibody, ME antibody, MME antibody, MMP 12 antibody, MMP12 antibody
- UniProt ID
- P39900
- Observed MW
- 54 kDa, 45 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05234(MMP12 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab05234(MMP12 Antibody) at dilution of 1:50
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed A549 cells using FNab05234 (MMP12 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).
