K-562 cells were subjected to SDS PAGE followed by western blot with FNab03803(HDAC6 antibody) at dilution of 1:1000
IP Result of anti-HDAC6 (IP:FNab03803, 5ug; Detection:FNab03803 1:1000) with K-562 cells lysate 11000ug.
Immunohistochemistry of paraffin-embedded human testis using FNab03803(HDAC6 antibody) at dilution of 1:50
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.