Products
ATF6B antibody
- Product Name
- ATF6B antibody
- Catalogue No.
- FNab00665
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- activating transcription factor 6 beta
- Alternative Names
- CREBL1 antibody, G13 antibody
- UniProt ID
- Q99941
- Observed MW
- 110 kDa, 60 kDa, 80 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:1000-1:4000; IP:1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab00665(ATF6B antibody) at dilution of 1:1000
IP Result of anti-ATF6B (IP:FNab00665, 4ug; Detection:FNab00665 1:1000) with Jurkat cells lysate 3200ug.
Immunohistochemistry of paraffin-embedded human brain using FNab00665(ATF6B antibody) at dilution of 1:100
- Background
- The endoplasmic reticulum (ER)-transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR). The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms(60,80kd )(PMID: 11256944)
