Products
AMACR/p504S antibody
- Product Name
- AMACR/p504S antibody
- Catalogue No.
- FNab00355
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- alpha-methylacyl-CoA racemase
- Alternative Names
- 2 methylacyl CoA racemase antibody, alpha methylacyl CoA racemase antibody, AMACR antibody, CBAS4 antibody, p504S antibody, RACE antibody
- UniProt ID
- Q9UHK6
- Observed MW
- 42 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
Recombinant AMACR protein were subjected to SDS PAGE followed by western blot with FNab00355(AMACR Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab00355(p50S,AMACR antibody) at dilution of 1:50
- Background
- AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
