Products
ALK,CD246 antibody
- Product Name
- ALK,CD246 antibody
- Catalogue No.
- FNab00309
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- anaplastic lymphoma receptor tyrosine kinase
- Alternative Names
- ALK antibody, ALK tyrosine kinase receptor antibody, ALK antibody, CD246 antibody, Anaplastic lymphoma kinase antibody, CD246 antibody, TFG/ALK antibody
- UniProt ID
- Q9UM73
- Observed MW
- 140-220 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
Various lysates were subjected to SDS PAGE followed by western blot with FNab00309(ALK,CD246 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using FNab00309( ALK,CD246 Antibody) at dilution of 1:50
- Background
- Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
