Products
ESR2 antibody
- Product Name
- ESR2 antibody
- Catalogue No.
- FNab02867
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 0A10
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- estrogen receptor 2(ER beta)
- Alternative Names
- ER BETA antibody, Erb antibody, ESR BETA antibody, ESR2 antibody, ESRB antibody, ESTRB antibody, estrogen receptor 2 (ER beta) antibody, Estrogen receptor beta antibody, NR3A2 antibody
- UniProt ID
- Q92731
- Observed MW
- 50 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:2000
Validated Images
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab02867( ESR2 Antibody) at dilution of 1:1000
- Background
- Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements(ERE) in an estrogen-dependent manner(PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
