Products
AKAP10 antibody
- Product Name
- AKAP10 antibody
- Catalogue No.
- FNab00250
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- A kinase(PRKA) anchor protein 10
- Alternative Names
- AKAP10 antibody, D AKAP2 antibody, AKAP 10 antibody, PRKA10 antibody, D AKAP 2 antibody
- UniProt ID
- O43572
- Observed MW
- 74 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00250(AKAP10 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human cervical cancer using FNab00250(AKAP10 antibody) at dilution of 1:100
- Background
- Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase(By similarity).
