FineTest ELISA kit contributes to the research on autoimmune disease. The immunoassay is designed to measure TNF-α and IFN-γ concentration in serum.
Publication Details
Article Title: Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome
Journal Title: Annals of the Rheumatic Diseases
DOI: 10.1136/ard-2023-224930
IF: 27.4
PMID: 38331588
Abstract: Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disease. We aimed to reveal cellular compositions and molecular features of decidual cells involved in the development of OAPS using single-cell RNA sequencing (scRNA-seq). We performed unbiased scRNA-seq analysis on the first-trimester decidua from five OAPS patients and five healthy controls (HCs), followed by validations with flow cytometry, immunohistochemical staining and immunofluorescence in a larger cohort. Serum chemokines and cytokines were measured by using ELISA. The cellular interactions between decidual immune cells and those of immune cells with non-immune cells under disease state were altered, especially through chemokines, IFN-γ and TNF-α. This study provided a comprehensive decidual cell landscape and identified aberrant decidual microenvironment in OAPS, providing some potential therapeutic targets for this disease.
Keywords: Antibodies, Antiphospholipid, Antiphospholipid Syndrome, Autoimmune Diseases, Autoimmunity, Inflammation
Immunoassay
| FineTest Product | Sample | Species | Detection Target |
| Human TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit (EH0302) |
serum | Human | TNF-α |
| Human IFN-γ(Interferon gamma) ELISA Kit(EH0164) | IFN-γ |
Validated Image
Figure Source: Ann Rheum Dis. 2024 Feb 8:ard-2023-224930. doi: 10.1136/ard-2023-224930.