THP-1 cells were subjected to SDS PAGE followed by western blot with FNab10949(TMEM173 antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human tonsillitis using FNab10949(TMEM173 antibody) at dilution of 1:200
Background
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.