Products

SATB2 antibody

Synonyms:DNA binding protein SATB2 antibody, KIAA1034 antibody, SATB homeobox 2 antibody, SATB2 antibody
Catalogue No.:FNab10798Reativity:Human
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
SATB2 antibody
Catalogue No.
FNab10798
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
SATB homeobox 2
Alternative Names
DNA binding protein SATB2 antibody, KIAA1034 antibody, SATB homeobox 2 antibody, SATB2 antibody
UniProt ID
Q9UPW6
Observed MW
69-83 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab10798(SATB2 antibody) at dilution of 1:1000
Background
Binds to DNA, at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons(UL1) specific genetic program and for the inactivation of deep-layer neurons(DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.