HSD17B10 antibody

Synonyms:3-hydroxyacyl-CoA dehydrogenase type-2|17-beta-estradiol 17-dehydrogenase|2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD)|3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type II|3alpha(or 20beta)-hydroxysteroid dehydrogenase|7-alpha-hydroxysteroid dehydrogenase|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein|Mitochondrial ribonuclease P protein 2 (Mitochondrial RNase P protein 2)|Short chain dehydrogenase/reductase family 5C member 1|Short-chain type dehydrogenase/reductase XH98G2|Type II HADH|HSD17B10|ERAB|HADH2|MRPP2|SCHAD|SDR5C1|XH98G2 antibody
Catalogue No.:FNab10790Reactivity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
HSD17B10 antibody
Catalogue No.
FNab10790
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
hydroxysteroid(17-beta) dehydrogenase 10
Alternative Names
3-hydroxyacyl-CoA dehydrogenase type-2|17-beta-estradiol 17-dehydrogenase|2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD)|3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type II|3alpha(or 20beta)-hydroxysteroid dehydrogenase|7-alpha-hydroxysteroid dehydrogenase|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein|Mitochondrial ribonuclease P protein 2 (Mitochondrial RNase P protein 2)|Short chain dehydrogenase/reductase family 5C member 1|Short-chain type dehydrogenase/reductase XH98G2|Type II HADH|HSD17B10|ERAB|HADH2|MRPP2|SCHAD|SDR5C1|XH98G2 antibody
UniProt ID
Q99714
Observed MW
27 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
293T cells were subjected to SDS PAGE followed by western blot with FNab10790(ERAB antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat lung using FNab10790(ERAB antibody) at dilution of 1:100
Background
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease(AD).