Products

anti- PAR2 antibody

FNab10720 Catalogue No.
Synonyms:
F2RL1, G protein coupled receptor 11, GPR11, PAR 2, PAR2, Thrombin receptor like 1
Host:
Rabbit
Reactivity:
Human
Isotype:
IgG
Tested Application:
ELISA, IHC
Product Information
Product Name
anti- PAR2 antibody
Catalogue No.
FNab10720
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Proteinase-activated receptors(PARs) are G protein-coupled receptors activated through cleavage of their N-termini by mainly serine proteases. The family of PARs include four members: PAR1, PAR2, PAR3 and PAR4. PAR2, also known as F2RL1, is expressed in epithelial cells(e.g., lung, gastrointestinal tract), endothelial cells, smooth muscle cells, fibroblasts, nerves, and some immune and inflammatory cells. PAR2 knockout mice and PAR2 agonists and antagonists have implicated PAR2 as a promising target in inflammatory conditions; respiratory, gastrointestinal, metabolic, cardiovascular, and neurological dysfunction; and cancers.(PMID:23895492)
Immunogen Information
Immunogen
coagulation factor II(thrombin) receptor-like 1
Synonyms
F2RL1, G protein coupled receptor 11, GPR11, PAR 2, PAR2, Thrombin receptor like 1
Observed MW
50 kDa
Application
Tested Application
ELISA, IHC
Recommended dilution
IHC: 1:20-1:200
Uniprot information
UniProt ID
P55085
Images
Immunohistochemistry of paraffin-embedded human liver tissue slide using FNab10720(PAR2 antibody) at dilution of 1:100